Catharine (Katy) Bosio, Ph.D.
Chief, Immunity to Pulmonary Pathogens Section
NIAID, Rocky Mountain Labs, Hamilton, Montana, USA
Major Areas of Research
- Innate immunity to Francisella tularensis
- Vaccine development for pneumonic tularemia
- Modulation of human cells by F. tularensis
The focus of our research is to gain a better understanding of how aerosolized pathogens successfully infect and modulate the pulmonary environment to cause overt disease and death. Currently, our principal interest is the pathogenesis of aerosolized F. tularensis, the causative agent of pneumonic tularemia.
There are two primary areas of research ongoing in our laboratory: innate immunity to F. tularensis, and modulation of human cells by F. tularensis. We are particularly interested in modulation of primary antigen-presenting cells (dendritic cells and macrophages) by F. tularensis and how this modulation allows the bacterium to initially evade host immune responses immediately following infection. We utilize both in vivo and in vitro models of disease to reveal specific mechanisms at play in both host and pathogen to gain a better understanding of the dynamic nature of this disease.